Age and Susceptibility of Mice to Coxsackie a Viruses

Susceptibility of mice to group B coxsackie virus is influenced by the diabetic gene

A positive correlation was found between genetic predisposition to diabetes in the mouse and susceptibility to group B Coxsackie virus in this host. Male mice of the inbred strain C57BL/Ks and the following genetic variants were used; mice homozygous for the autosomal recessive gene for diabetes (db/db), the phenotypically normal heterozygous (db/+), and the normal mice which lacked the diabeti...

Vg1 T Cells Suppress and Vg4 T Cells Promote Susceptibility to Coxsackievirus B3-Induced Myocarditis in Mice

Antiviral activity of 10-carboxymethyl-9-acridanone.

Intraperitoneal administration of 10-carboxymethyl-9-acridanone sodium salt (CMA) protected at least 50% of mice tested from otherwise lethal infections with Semliki forest, coxsackie B1, Columbia SK, Western equine encephalitis, herpes simplex, and pseudorabies viruses. The protective effect against influenza A2/Asian/J305 and coxsackie A21 viruses was less but was statistically significant. W...

Virus-induced diabetes mellitus. XV. Beta cell damage and insulin- dependent hyperglycemia in mice infected with coxsackie virus B4

Coxsackie virus B4 that had been passaged in cultures enriched for pancreatic beta cells produced a diabetes-like syndrome when inoculated into SJL/J mice. The infection resulted in insulitis and destruction of beta cells. Viral antigens were found in beta cells by staining with fluorescein-labeled antibody to Coxsackie virus B4. The destruction of beta cells led to a decrease in the immunoreac...

Fuchsinophile Granules in the Tissues of Mice Infected with the Connecticut-5 Strain of Coxsackie Virus

Minute cytoplasmic fuchsinophilic granules, characteristically surrounded by a halo, have been demonstrated in the lesions produced in suckling mice by the Connecticut-5 strain of Coxsackie virus. Their possible significance is discussed.